2022 World Conference on Lung Cancer (ePosters)-EP14.02-001. Could the Oxidative Stress Be Used as a Marker for Neuroendocrine Lung Tumors?

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In this study, the researchers aim to investigate whether oxidative stress could be used as a marker for neuroendocrine lung tumors compared to other types of tumors. They also try to identify specific markers of oxidative stress in these tumors. The study was conducted on 84 patients who underwent surgery for typical carcinoid, atypical carcinoid, and large cell neuroendocrine carcinoma. <br /><br />The researchers analyzed the levels of vascular density, VEGFA, and somatostatin type-2 receptor (SSTR2) in serum and tissue samples to assess angiogenesis in these tumors. They also compared oxidative stress parameters such as soluble Nox2-derived peptide (sNOX2-dp) release, hydrogen peroxide (H2O2) production, H2O2 break-down activity (HBA), and endothelial dysfunction in the study group. <br /><br />The results showed that the vascular density was higher in low-grade tumors, which is known as the "neuroendocrine paradox." This suggests that angiogenesis may serve as a differentiation marker rather than a prognostic marker in neuroendocrine tumors. <br /><br />The study also found that oxidative stress parameters were higher in neuroendocrine tumors compared to non-small cell lung cancer and healthy individuals. This suggests that oxidative stress may have a prominent role in neuroendocrine lung tumors. <br /><br />The researchers conclude that if further studies confirm the role of oxidative stress in neuroendocrine lung tumors, it could provide new perspectives for the development of new drug treatments. Overall, this study highlights the potential of oxidative stress as a marker and therapeutic target in neuroendocrine lung tumors.

Asset Subtitle

Luigi Gaetano Andriolo

Meta Tag

Speaker Luigi Gaetano Andriolo

Topic Small Cell Lung Cancer and Neuro-endocrine Tumours - Preclinical/Translational

Keywords

oxidative stress

neuroendocrine lung tumors

marker

specific markers

vascular density

angiogenesis

soluble Nox2-derived peptide

hydrogen peroxide

endothelial dysfunction

therapeutic target