2022 World Conference on Lung Cancer (ePosters)-EP14.05-006. The Impact of Adjuvant Chemotherapy on Survival of Stage I Lung Large Cell Neuroendocrine Carcinoma: A Meta-Analysis of Comparative Studies

EP14.05-006. The Impact of Adjuvant Chemotherapy on Survival of Stage I Lung Large Cell Neuroendocrine Carcinoma: A Meta-Analysis of Comparative Studies

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In this study, a meta-analysis was conducted to evaluate the impact of adjuvant chemotherapy on the survival of patients with stage I lung large cell neuroendocrine carcinoma (LCNE). LCNE is a less common and aggressive type of lung cancer, and surgical resection is the standard treatment for early stages. However, recurrences are common and mortality is high. The role of adjuvant chemotherapy in stage I LCNE has been controversial, and optimal strategies are not well-defined.<br /><br />The previous meta-analysis that analyzed the same data from the National Cancer Database (NCDB) and included both LCNE and small cell lung cancer was flawed. Therefore, this meta-analysis aimed to assess the impact of adjuvant chemotherapy on overall survival specifically in patients with completely resected stage I LCNE, incorporating more recent studies.<br /><br />The researchers conducted a review of the medical literature and included seven retrospective comparative studies with a total of 2,159 patients. The meta-analysis revealed that adjuvant chemotherapy was associated with a lower relative risk of death in patients with stage I LCNE. There was also a significantly lower relative risk of death in patients with stage IA and stage IB specifically. These findings suggest that adjuvant chemotherapy may be beneficial for patients with stage I LCNE.<br /><br />It is important to note that this meta-analysis was conducted in the absence of randomized clinical trials, which limits the level of evidence. However, it represents the most compelling data supporting the use of adjuvant chemotherapy in this specific patient population.<br /><br />In conclusion, this meta-analysis suggests that adjuvant chemotherapy may improve survival outcomes for patients with completely resected stage I LCNE. Further research, including randomized clinical trials, is needed to confirm these findings and determine the optimal adjuvant strategies for this rare and aggressive type of lung cancer.

Asset Subtitle

Philip A Haddad

Meta Tag

Speaker Philip A Haddad

Topic Small Cell Lung Cancer and Neuro-endocrine Tumours - RW/SOC

Keywords

meta-analysis

adjuvant chemotherapy

survival

stage I

lung large cell neuroendocrine carcinoma

LCNE

surgical resection

recurrences

mortality

optimal strategies