2022 World Conference on Lung Cancer (ePosters)-EP14.05-021. Promising Long-Term Survival after Surgical Resection of Early Stage Small Cell Lung Cancer in a Modern Single-Center Cohort

EP14.05-021. Promising Long-Term Survival after Surgical Resection of Early Stage Small Cell Lung Cancer in a Modern Single-Center Cohort

Back to course

Pdf Summary

A single-center study examined the outcomes of surgical resection in patients with early stage small cell lung cancer (SCLC). The study found that the frequency of SCLC surgical resection has increased in recent years, with more than one-third of cases occurring in the last three years. Recent patients had lower clinical and pathologic stages compared to earlier patients. Screening identified a higher proportion of early-stage SCLC in recent cases. The 5-year overall survival (OS) was 25.3%, and the median OS was 32 months. Stage I patients had an excellent 5-year OS of 78%. The study suggests that the observed disease-free survival (DFS) and OS in their single-center series exceed previous national reports. This is particularly promising for stage I cases. The study also highlights the potential impact of screening on the diagnosis and outcome of SCLC. However, longer follow-up and more data are needed to validate these findings and determine if they translate into a significant improvement in survival. The study included 27 patients with highly racially homogeneous demographics. Most patients underwent lobectomy, and only a minority had a preoperative SCLC diagnosis. The follow-up data was available for all patients. The overall median DFS was 29 months, with higher DFS in stage I patients. The differences in survival outcomes between the groups were not statistically significant in this small sample size. These findings contribute to the ongoing debate about the value and implementation of surgery in limited-stage SCLC.

Asset Subtitle

Sora Ely

Meta Tag

Speaker Sora Ely

Topic Small Cell Lung Cancer and Neuro-endocrine Tumours - RW/SOC

Keywords

surgical resection

small cell lung cancer

SCLC

outcomes

frequency

clinical stages

pathologic stages

screening

overall survival

disease-free survival