2022 World Conference on Lung Cancer (ePosters)-EP16.01-012. Immunophenotyping of Lung Adenocarcinoma in situ Based on CD8-positive T Cell Infiltration

EP16.01-012. Immunophenotyping of Lung Adenocarcinoma in situ Based on CD8-positive T Cell Infiltration

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In this study, the authors aimed to investigate the immunophenotyping of lung adenocarcinoma in situ (AIS) based on CD8-positive T cell infiltration, and its changes as the disease progressed to minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC). They analyzed tissue samples from 14 AIS patients, 17 MIA patients, and 40 IAC patients for CD8 T cell infiltration. <br /><br />The results showed that the proportion of CD8-positive T cells infiltrated in AIS was significantly lower than in MIA and IAC. The authors also performed immunophenotyping based on CD8 T cells and found that the immune excluded type was not observed in any type of lung adenocarcinoma. In AIS, a majority of patients were classified as immune desert, while in MIA, most were classified as inflamed. When the tumor progressed to IAC, a significant number of patients were also classified as inflamed.<br /><br />The study also analyzed the association between the histologic subtype of lung adenocarcinoma and immune subgroups. No significant differences were found in terms of gender, tumor diameter, or radiological type. However, the distribution of immune subgroups varied between AIS, MIA, and IAC.<br /><br />In conclusion, the infiltration of CD8-positive T cells increases as lung adenocarcinoma progresses from AIS to IAC. The immunophenotype of AIS is mainly immune desert, while MIA and IAC are mainly inflamed types. These findings provide insights into the immune microenvironment of lung adenocarcinoma at different stages, which may have implications for therapeutic strategies targeting immune responses in patients with this type of cancer.

Asset Subtitle

Yu Ma

Meta Tag

Speaker Yu Ma

Topic Tumour Biology and Biomarkers - Immune Biology & Immunotherapy

Keywords

lung adenocarcinoma

immunophenotyping

CD8-positive T cells

infiltration

adenocarcinoma in situ

minimally invasive adenocarcinoma

invasive adenocarcinoma

immune excluded type

immune desert

inflamed type