2022 World Conference on Lung Cancer (ePosters)-EP16.01-019. The Role of the Pregnancy Associated Protein Glycodelin and Its Influence on the Immune System in Non-small-Cell Lung Cancer

EP16.01-019. The Role of the Pregnancy Associated Protein Glycodelin and Its Influence on the Immune System in Non-small-Cell Lung Cancer

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This study explores the role of the pregnancy-associated protein glycodelin in non-small-cell lung cancer (NSCLC) and its influence on the immune system. The researchers discovered high levels of glycodelin in NSCLC tissue and identified its encoding gene as being highly expressed in tumors but not in non-neoplastic tissue. Glycodelin is known to be involved in successful fertilization and trophoblast invasion during pregnancy. The study aimed to determine if glycodelin in NSCLC has similar characteristics to the immunosuppressive glycodelin A found in pregnancy, potentially leading to immune-escape of the tumor. The researchers conducted various experiments to analyze the glycosylation pattern of glycodelin in NSCLC and its effect on immune cells. They found that glycodelin from NSCLC shares a similar glycosylation pattern with glycodelin A and acts on immune cells related to the tumor microenvironment. Additionally, they observed that high glycodelin serum levels in NSCLC patients led to an impaired progression-free survival, particularly in female patients. The researchers also found that glycodelin binds to immune cells both in vitro and in vivo. These findings suggest that glycodelin may have a role as an immunosuppressor in NSCLC and that it could be a novel target in immuno-oncology. The study concludes by outlining future research avenues, such as investigating the interaction between glycodelin and the immune environment in ex vivo models and exploring the influence of hormonal factors on glycodelin's predictive value.

Asset Subtitle

Sarah Richtmann

Meta Tag

Speaker Sarah Richtmann

Topic Tumour Biology and Biomarkers - Immune Biology & Immunotherapy

Keywords

pregnancy-associated protein

glycodelin

non-small-cell lung cancer

NSCLC

immune system

tumor microenvironment

glycosylation pattern

immunosuppressor

progression-free survival

immuno-oncology