2022 World Conference on Lung Cancer (ePosters)-EP16.01-025. Immune Evolution of Metastases & Underlying Molecular Mechanisms in Non-small Cell Lung Cancer

EP16.01-025. Immune Evolution of Metastases & Underlying Molecular Mechanisms in Non-small Cell Lung Cancer

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The study investigates the immune evolution and molecular mechanisms underlying metastases in non-small cell lung cancer (NSCLC). Researchers analyzed samples from primary tumors, lymph nodes, local metastases (pleural), and distant metastases (brain, bone, adrenal gland) from NSCLC patients. Whole-exome sequencing and immunohistochemistry were performed to assess genetic factors and immune profiles. The findings indicate that acquired DNA damage response (DDR) deficiency is associated with NSCLC metastasis. Immunosuppression was observed in distant metastases but not in local metastases. Distant metastases exhibited lower levels of CD8 and higher levels of CD4 and PD-L1 compared to local metastases. Acquired DDR deficiency was found to drive immunosuppression in distant metastases by increasing chromosomal instability. Moreover, the immune background of primary tumors may influence metastatic destinations. The study concludes that acquired DDR deficiency plays a role in driving immunosuppression in distant metastases in NSCLC. Additionally, immune profiles differ between distant and local metastases, and the immune background of primary tumors may impact metastatic destinations. These findings enhance our understanding of immune evolution and molecular mechanisms in NSCLC metastases and could have implications for developing targeted therapies. Further research is necessary to validate and expand on these findings.

Asset Subtitle

Wen-Fang Tang

Meta Tag

Speaker Wen-Fang Tang

Topic Tumour Biology and Biomarkers - Immune Biology & Immunotherapy

Keywords

metastases

NSCLC

primary tumors

distant metastases

immune profiles

DDR deficiency

immunosuppression

CD8

PD-L1

chromosomal instability