2022 World Conference on Lung Cancer (ePosters)-EP16.02-021. The Expression of CEACAMs and Serum CEA Levels as Biomarkers of Postoperative Cancer Recurrence in Non-small Cell Lung Cancer

EP16.02-021. The Expression of CEACAMs and Serum CEA Levels as Biomarkers of Postoperative Cancer Recurrence in Non-small Cell Lung Cancer

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A study conducted at Seoul National University investigated the use of serum carcinoembryonic antigen (CEA) levels and the gene expression of CEA-related cell adhesion molecules (CEACAMs) as biomarkers for predicting postoperative cancer recurrence in non-small cell lung cancer (NSCLC). The researchers hypothesized that elevated CEACAM expression and elevated serum CEA levels may be indicative of recurrence.<br /><br />The study involved 157 NSCLC patients who underwent surgery and had access to cancer specimens for analysis. Whole transcriptome sequencing (WTS) and CEA level measurements were performed. The data revealed that pre- or post-CEA levels greater than 10 ng/ml were significantly associated with recurrence, especially in patients with high CEACAM expression in their cancer tissue. However, it was also observed that some patients had low post-CEA levels despite elevated CEACAM levels, suggesting a novel molecular mechanism controlling the leakage of cancer cell proteins into the bloodstream.<br /><br />The study also found that CEACAMs were frequently overexpressed in the majority of cases, with CEACAM5 and CEACAM6 showing a significant correlation in expression levels. Furthermore, patients with elevated CEA levels often expressed high levels of CEACAM5 and CEACAM6, indicating that the elevated serum CEA levels were caused by leakage from cancer tissue.<br /><br />Interestingly, some patients with elevated CEACAM expression showed low post-CEA levels during recurrence, suggesting the presence of a different mechanism regulating the entry of cancer cell proteins into the bloodstream.<br /><br />In conclusion, the study suggests that elevated CEACAMs expression and serum CEA levels may be useful biomarkers for predicting postoperative cancer recurrence in NSCLC. However, the study also highlights the need for further research to uncover the underlying mechanisms controlling the leakage of cancer cell proteins into the bloodstream.

Asset Subtitle

Bubse Na

Meta Tag

Speaker Bubse Na

Topic Tumour Biology and Biomarkers - Minimally Invasive Biomarkers

Keywords

Seoul National University

CEA levels

gene expression

biomarkers

cancer recurrence

NSCLC

transcriptome sequencing

CEACAMs

cancer cell proteins

underlying mechanisms