2022 World Conference on Lung Cancer (ePosters)-EP16.03-007. Comprehensive Analysis of m6A-Related Gene Mutation Characteristics and Prognosis in Lung Adenocarcinoma

EP16.03-007. Comprehensive Analysis of m6A-Related Gene Mutation Characteristics and Prognosis in Lung Adenocarcinoma

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This study aimed to characterize the mutation of m6A related genes and explore their prognostic role in lung adenocarcinoma (LUAD). The researchers analyzed RNA-seq data and somatic mutation data from TCGA-LUAD dataset. They found that m6A related genes have a high mutation frequency in LUAD, with CA and CT being the main mutation types. Patients with high expressions of HNRNPC, IGF2BP1, IGF2BP2, IGF2BP3, and METTL5 showed poor prognosis in LUAD. They also found correlations between these genes and clinical parameters and immune-related indicators. HNRNPC was mainly enriched in ribonucleoprotein complex biogenesis, IGF2BP1 was related to the mitotic cell cycle checkpoint, and IGF2BP3 was related to the nuclear division pathway.<br /><br />The study identified novel immune-related prognostic markers and investigated the potential mechanisms of these markers in regulating the etiology of LUAD. These findings contribute to a better understanding of the relationships between m6A-related genes and LUAD and may provide new ideas for the treatment of LUAD patients.

Asset Subtitle

Jing-Hua Chen

Meta Tag

Speaker Jing-Hua Chen

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

mutation

m6A related genes

prognostic role

lung adenocarcinoma

LUAD

RNA-seq data

somatic mutation data

TCGA-LUAD dataset

poor prognosis

immune-related indicators