2022 World Conference on Lung Cancer (ePosters)-EP16.03-008. The Landscape of NFE2L2 Alteration in Chinese Lung Cancer Patients

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This study aimed to describe the landscape of NFE2L2 gene alterations in lung cancer patients in China. The researchers analyzed 1103 samples from patients with lung cancer using next-generation sequencing and identified alterations including single base substitutions, insertions/deletions, copy number variations, gene fusions, and rearrangements. They found that NFE2L2 gene was altered in 3% of all lung cancer samples, with higher frequencies in squamous cell carcinoma (16.2%) compared to adenocarcinoma (1.5%). The study also showed that NFE2L2 variations were correlated with the amplification of chromosome 3q26, which is more common in squamous cell carcinoma. In terms of survival analysis, the patients with NFE2L2 variations and 3q26 amplification had a longer median survival compared to those without 3q26 amplification. The study also identified other actionable or driver mutations in NFE2L2 mutation carriers, with TP53 being the most frequent one. Multivariate Cox regression analysis showed that the co-occurrence of NFE2L2 variation and 3q26 amplification was a significant predictor of overall survival. The researchers concluded that NFE2L2 deleterious mutations are diverse and present at low to moderate frequencies in lung cancer, and that further studies should consider the genomic characterization and prognostic analysis among the NFE2L2 population in lung cancer.

Asset Subtitle

Xuejun Dou

Meta Tag

Speaker Xuejun Dou

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

NFE2L2 gene alterations

lung cancer patients

China

next-generation sequencing

squamous cell carcinoma

adenocarcinoma

chromosome 3q26 amplification

survival analysis

actionable mutations

deleterious mutations