2022 World Conference on Lung Cancer (ePosters)-EP16.03-010. Molecular and Clinical Characterization of Lung Adenocarcinoma With Respect to Patient Age at Diagnosis

EP16.03-010. Molecular and Clinical Characterization of Lung Adenocarcinoma With Respect to Patient Age at Diagnosis

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This study aimed to investigate the differences in clinical characteristics and molecular alterations in early-stage lung adenocarcinoma patients based on age at diagnosis. The results suggest that age does not add complexity beyond genetic and transcriptional phenotypes, but it does influence treatment decisions and the presence of actionable mutations. The study analyzed various cohorts, including DNA alterations, epigenetic alterations, immune composition, and transcriptional patterns. DNA methylation patterns revealed different clusters stratified by age groups, indicating an influence on epigenetic profiles. The document includes charts and tables depicting data on age groups, CpG clustering, Copy Number Alterations (CNAs), and genetic mutations. It shows that CpG clusters do not distinctly separate age groups, and mutations in EGFR, TP53, and KRAS decrease with age. There were no clear patterns in CNA frequencies between age groups. The document also provides information on subtype cases in different cohorts, with significant differences observed over age groups. Copy number gains and losses were observed in various chromosomes. The document suggests that age does not strongly capture transcriptional variation in the cohorts. Overall, the document highlights the genetic and epigenetic alterations observed across age groups and their implications on lung adenocarcinoma.

Asset Subtitle

Elsa Arbajian

Meta Tag

Speaker Elsa Arbajian

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

clinical characteristics

molecular alterations

lung adenocarcinoma

age at diagnosis

genetic phenotypes

transcriptional phenotypes

DNA alterations

epigenetic alterations

CpG clustering

genetic mutations