2022 World Conference on Lung Cancer (ePosters)-EP16.03-015. Centrosome Amplification Is a Prognostic Indicator and Potential Therapeutic Vulnerability in Non-small Cell Lung Cancer

EP16.03-015. Centrosome Amplification Is a Prognostic Indicator and Potential Therapeutic Vulnerability in Non-small Cell Lung Cancer

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Centrosome amplification (CA) is an increase in the number of centrosomes in cells, which can lead to chromosome segregation errors and promote tumor progression. In this study, the researchers aimed to characterize CA in non-small cell lung cancer (NSCLC) and investigate its clinical significance. They used gene expression data from multiple cohorts to infer CA and found that CA20 scores, a measure of CA, were higher in lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC) compared to non-malignant tissues. They also found a positive correlation between CA20 scores and genomic instability in the TCGA LUAD and LUSC cohorts. <br /><br />The researchers observed that CA20 scores were higher in current and former smokers, as well as in tumors with higher stage. They also found that CA20 scores were lower in tumors with EGFR and KRAS mutations compared to those without mutations. Additionally, high CA20 scores were associated with worse survival in TCGA LUAD patients, although this association was not significant in smaller cohorts. Immunohistochemistry experiments confirmed the presence of CA in NSCLC tissues.<br /><br />Based on their findings, the researchers concluded that CA is common in NSCLC and may be associated with genomic instability, smoking history, and survival. They suggested that CA could be a targetable vulnerability in NSCLC and recommended further studies to assess its therapeutic potential. Future directions include characterizing CA using immunohistochemistry in a larger NSCLC cohort, evaluating the efficacy of CA20 as a predictor of CA, and exploring therapeutic approaches targeting CA in NSCLC.

Asset Subtitle

Kelsie Thu

Meta Tag

Speaker Kelsie Thu

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

Centrosome amplification

chromosome segregation errors

tumor progression

NSCLC

genomic instability

EGFR mutations

KRAS mutations

survival

immunohistochemistry