2022 World Conference on Lung Cancer (ePosters)-EP16.03-022. Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Sampling Is Sufficient for Lung Cancer Molecular Profiling

EP16.03-022. Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Sampling Is Sufficient for Lung Cancer Molecular Profiling

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This document is a summary of a study conducted to evaluate the use of next-generation sequencing (NGS) of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples for molecular profiling and initiation of appropriate treatment in patients with non-small cell lung cancer (NSCLC).<br /><br />The study included a retrospective chart review of 44 patients diagnosed with stage III or IV NSCLC who had NGS performed on EBUS-TBNA samples. The EBUS-TBNA samples were formed from multiple aspirates pooled into a cell culture solution and then sent for NGS. Patient demographics, smoking history, clinical stage, histology, detection of genomic biomarkers, biopsy turnaround time, treatment decisions, treatment regimens, and response to therapy were collected from the electronic medical record.<br /><br />The results showed that EBUS-TBNA samples were sufficient for NGS in 95.5% of patients. The median turnaround time for tissue NGS was 38.5 days compared to 8 days for liquid biopsy (LB) NGS. Thirty patients had actionable genetic aberrations (AGA), including BRAF, EGFR, KRAS, MET, NTRK1, and PD-L1. All AGA identified by LB were also found by EBUS-TBNA.<br /><br />The study concludes that EBUS-TBNA is a successful and minimally invasive method to obtain sufficient tissue samples for the identification of AGA in patients with advanced NSCLC. It suggests that EBUS-TBNA could be incorporated as a standard of care for guiding first-line therapy decisions. However, the authors recommend further prospective studies with a larger sample size to validate these results.<br /><br />In summary, this study highlights the potential of using NGS of EBUS-TBNA samples for molecular profiling and initiating appropriate treatment in patients with NSCLC. EBUS-TBNA appears to be an effective and minimally invasive technique for obtaining sufficient tissue samples for molecular analysis.

Asset Subtitle

Luis Raez

Meta Tag

Speaker Luis Raez

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

next-generation sequencing

endobronchial ultrasound-guided transbronchial needle aspiration

EBUS-TBNA

molecular profiling

non-small cell lung cancer

NSCLC

retrospective chart review

genomic biomarkers

liquid biopsy

actionable genetic aberrations