2022 World Conference on Lung Cancer (ePosters)-EP16.03-033. Transcriptomic Heterogeneity in Non-Small Cell Lung Cancer with Four Structure-Based EGFR-Mutation Subgroups

EP16.03-033. Transcriptomic Heterogeneity in Non-Small Cell Lung Cancer with Four Structure-Based EGFR-Mutation Subgroups

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This study aimed to understand the biological characteristics and heterogeneity of non-small cell lung cancer (NSCLC) driven by different EGFR (epidermal growth factor receptor) mutations. The researchers classified EGFR mutations into four subtypes based on unique structures. They analyzed 119 NSCLC patients with EGFR mutations and compared the biological differences between the subtypes.<br /><br />The study found that the T790M-like subgroup displayed lower anti-tumor immune signatures, such as T cell infiltration, compared to other subgroups. On the other hand, there was significant enrichment of tumor proliferation signatures in the T790M-like group. The Classical-like group showed enrichment of immune-related pathways, while the PACC subgroup displayed activation of G-protein-coupled receptors signaling cascade.<br /><br />Transcriptomic heterogeneity was observed in the four EGFR mutation subgroups. The T790M-like group showed upregulation of cell cycle-related pathways, while the Ex20ins subgroup was characterized by enrichment of oncogenic processes. The immune characteristics of tumors with different subtypes were also investigated.<br /><br />Overall, this study demonstrated the heterogeneity of NSCLC driven by distinct EGFR mutations at the transcriptional and functional level. Understanding the biology of NSCLC with different EGFR mutation subtypes is crucial for developing targeted therapies in the future. The study provides valuable insights into the biological characteristics of NSCLC and highlights the need for further research in this area.

Asset Subtitle

Shun Lu

Meta Tag

Speaker Shun Lu

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

non-small cell lung cancer

NSCLC

EGFR mutations

biological characteristics

heterogeneity

T790M-like subgroup

immune signatures

tumor proliferation

Classical-like group

PACC subgroup