2022 World Conference on Lung Cancer (ePosters)-EP16.03-036. Clinical and Genomic Features of HER2 exon 20 Insertion Mutations in East Asian NSCLC

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This study focused on characterizing the clinical and genomic features of HER2-mutated non-small cell lung cancer (NSCLC) with a specific focus on HER2 exon 20 insertion mutations (HER2ex20) in East Asian patients. The researchers aimed to describe the prevalence and compare the clinical and genomic features of HER2ex20 mutations to other HER2 mutations (HER2other). The study analyzed lung adenocarcinoma patients diagnosed between June 2019 and June 2021 using next-generation sequencing (NGS) and electronic health records.<br /><br />The findings of the study revealed that the incidence of HER2-mutated NSCLC was 3.1% in East Asian non-squamous NSCLC, with HER2ex20 mutations comprising 2.7% of cases. The clinical and genomic features of HER2ex20 tumors appeared distinct from HER2other tumors. HER2ex20 mutations were associated with a lower tumor mutational burden (TMB), a lower frequency of cancer driver co-mutations, and a predominance of an aging mutational signature. On the other hand, HER2other mutations were associated with a higher TMB, a higher frequency of cancer driver mutations, and a greater presence of smoking and APOBEC mutational signature.<br /><br />The study also found that simultaneous EGFR mutations were observed in 3.8% of HER2ex20 mutated cases and 30.8% of HER2other mutated cases. Co-mutations in TP53 were identified in 23.1% of HER2ex20 mutated cases and 7.7% of HER2other mutated cases.<br /><br />The results of this study highlight the distinct clinical and genomic characteristics of HER2ex20 mutations in East Asian NSCLC patients and suggest that these mutations may require different treatment strategies compared to other HER2 mutations. Further investigation is needed to understand the therapeutic implications of these findings.

Asset Subtitle

Stephanie Pei Li Saw

Meta Tag

Speaker Stephanie Pei Li Saw

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

HER2-mutated NSCLC

HER2 exon 20 insertion mutations

East Asian patients

prevalence

clinical features

genomic features

tumor mutational burden

cancer driver co-mutations

EGFR mutations

TP53 co-mutations