2022 World Conference on Lung Cancer (ePosters)-EP16.03-040. Biomarkersatlas.com: the Italian NSCLC Precision Medicine Knowledge Data Base

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The study discussed in the document focuses on the development of a knowledge-based system called the Italian NSCLC Precision Medicine Knowledge Data Base to support clinicians in managing non-small cell lung cancer (NSCLC) patients. With the increasing number of predictive biomarkers and targeted therapies, it is crucial to identify each actionable molecular alteration in order to guide treatment decisions. The system includes information on genomic alterations in four genes (EGFR, KRAS, NRAS, and BRAF) obtained from 608 advanced NSCLC patients and their clinical data.<br /><br />The study found a total of 62 unique genomic alterations across the four genes, with EGFR being the most frequently altered gene. The clinical data revealed that the majority of patients were female and between the ages of 60-80 years. Adenocarcinoma was the most common histological subtype, and a significant number of patients were never smokers. The most common treatment received was targeted therapy.<br /><br />The knowledge-based system provides links to PubMed indexed references and clinical trials, enhancing the reliability and usefulness of the database. The study concludes that the Italian NSCLC Precision Medicine Knowledge Data Base is reliable and supports its implementation in clinical practice. Furthermore, the program is expanding to include a total of 23 Italian institutions in 2022.<br /><br />Overall, this study highlights the importance of comprehensive molecular profiling in NSCLC patients and the need for knowledge-based systems to guide clinicians in the management of patients based on their specific molecular alterations. The data presented in the study provide valuable insights into the prevalence of different genomic alterations in NSCLC and their association with clinical characteristics.

Asset Subtitle

Umberto Malapelle

Meta Tag

Speaker Umberto Malapelle

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

Italian NSCLC Precision Medicine Knowledge Data Base

clinicians

non-small cell lung cancer

predictive biomarkers

targeted therapies

genomic alterations

EGFR

KRAS

NRAS

BRAF