2022 World Conference on Lung Cancer (ePosters)-EP16.03-047. Genomic Landscape of Squamous Cell Carcinoma Lung in an Indian Cohort

EP16.03-047. Genomic Landscape of Squamous Cell Carcinoma Lung in an Indian Cohort

Pdf Summary

A study conducted in India aimed to understand the genomic landscape of squamous cell carcinoma of the lung (SQCC). The study included 72 cases and used Clinical Exome Sequencing to identify alterations in their genetic makeup. The researchers identified 20 significantly mutated genes among a total of 9126 alterations detected. The top 10 genes included TP53, CDKN2A, NFE2L2, FGFR1, NAV3, PTEN, PIK3CA, CDH10, FAT4, and KRAS. The study also found EGFR activating mutations in 3.2% of cases, with del19 being present in 0.8% and L858R in 2.4% of cases. Other targetable alterations detected included BRAF V600E, ALK rearrangements, and KRAS G12C. The study also identified mutually exclusive genetic alterations and found associations with clinical characteristics such as early TNM stages. The researchers noted differences in prevalence and targetable alterations compared to previous studies conducted on different populations. The study concluded that about 24% of cases may be potentially druggable in the future. However, it was also observed that targeted agents developed for lung adenocarcinoma are largely ineffective against squamous cell carcinoma. The study highlights the need for further research and insights into the tumorigenesis of SQCC and the existence of distinct ethnic differences in the genomic landscape.

Asset Subtitle

Ullas Batra

Meta Tag

Speaker Ullas Batra

Topic Tumour Biology and Biomarkers - Molecular Profiling and Targeted Therapies

Keywords

genomic landscape

squamous cell carcinoma

Clinical Exome Sequencing

significantly mutated genes

EGFR activating mutations

BRAF V600E

ALK rearrangements

KRAS G12C

targetable alterations

ethnic differences