2022 World Conference on Lung Cancer (ePosters)-EP16.04-008. Cytotoxic Effects of Carnosic Acid Are Mediated by Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling in H1299 NSCLC Cells

EP16.04-008. Cytotoxic Effects of Carnosic Acid Are Mediated by Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling in H1299 NSCLC Cells

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This study investigated the cytotoxic effects of carnosic acid (CA) on non-small cell lung cancer (NSCLC) cells. The researchers found that CA decreased cell viability and induced apoptosis in NSCLC cells. They also demonstrated that CA increased the levels of sestrin-2, LKB1, and AMP-activated protein kinase (AMPK) signaling in these cells, suggesting the involvement of the Sestrin-2/LKB1/AMPK pathway in CA's anticancer effects. Additionally, the researchers observed that CA induced autophagy in NSCLC cells. The study suggests that CA exerts its anticancer properties through the induction of autophagy and activation of the Sestrin-2/LKB1/AMPK signaling pathway.<br /><br />Previous studies have shown that rosemary extract inhibits proliferation, survival, and migration of NSCLC cells and activates the AMPK pathway, which is consistent with the findings of this study. The researchers focused on CA, a major component of rosemary extract, to investigate its potential anticancer properties. The results suggest that CA may have therapeutic potential for NSCLC treatment.<br /><br />Future studies will further investigate the specific roles of the Sestrin-2/LKB1/AMPK signaling pathway in the mechanism of action of CA. SiRNA and small molecule inhibitors will be used to elucidate the functions of these signaling molecules. Tumor xenograft models will also be used to assess the anticancer properties of CA in vivo.<br /><br />In summary, this study provides evidence that CA inhibits cell viability and induces apoptosis in NSCLC cells. The underlying mechanism involves the induction of autophagy and activation of the Sestrin-2/LKB1/AMPK signaling pathway. These findings suggest that CA may be a potential therapeutic option for NSCLC treatment.

Asset Subtitle

Eric Jordan O'Neill

Meta Tag

Speaker Eric Jordan O'Neill

Topic Tumour Biology and Biomarkers - Tumour Biology & Preclinical Studies

Keywords

carnosic acid

non-small cell lung cancer

cytotoxic effects

cell viability

apoptosis

sestrin-2

LKB1

AMP-activated protein kinase

autophagy

anticancer properties