2022 World Conference on Lung Cancer (ePosters)-EP16.04-016. Overexpression of CEACAM6 Activates Src-FAK Signaling and Inhibits Anoikis, through Homophilic Interactions in Lung Adenocarcinomas

EP16.04-016. Overexpression of CEACAM6 Activates Src-FAK Signaling and Inhibits Anoikis, through Homophilic Interactions in Lung Adenocarcinomas

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The study conducted by Eun Young Kim and colleagues from Yonsei University College of Medicine in Seoul, South Korea focused on the overexpression of CEACAM6, a type of protein found in lung adenocarcinomas. The researchers aimed to investigate the role of CEACAM6 in lung cancer and its relationship with patient prognosis. <br /><br />Through the use of CellphoneDB, which analyzes single-cell RNA sequencing data, the researchers found that CEACAM6 molecules in lung cancer cells engage in significant homophilic interactions. Immunohistochemical staining of lung adenocarcinoma samples revealed that CEACAM6 was overexpressed in 80.1% of cases and that its overexpression was associated with a poorer prognosis, particularly in non-smokers and individuals with activating epidermal growth factor receptor mutations. <br /><br />Furthermore, the researchers conducted experiments to investigate the intracellular location and functional effects of CEACAM6. Immunoblotting and immunocytochemistry confirmed that CEACAM6 was predominantly present on the cancer cell surface and interacted with other cancer cells in the tumor microenvironment. CEACAM6 overexpression was found to activate the Src-FAK signaling pathway and inhibit anoikis, a form of cell death that occurs when cells detach from the extracellular matrix. <br /><br />The study highlights the potential therapeutic significance of inhibiting CEACAM6 or its interactions in lung cancer cells. By understanding the molecular mechanisms involved in CEACAM6-mediated tumor growth and survival, researchers may be able to develop novel treatment strategies for patients with lung adenocarcinoma.

Asset Subtitle

Eun Young Kim

Meta Tag

Speaker Eun Young Kim

Topic Tumour Biology and Biomarkers - Tumour Biology & Preclinical Studies

Keywords

CEACAM6

lung adenocarcinomas

overexpression

patient prognosis

CellphoneDB

homophilic interactions

immunohistochemical staining

non-smokers

epidermal growth factor receptor mutations

tumor microenvironment