2022 World Conference on Lung Cancer (ePosters)-EP16.04-018. DNA Mismatch Repair in Lung Adenocarcinoma in Morocco

EP16.04-018. DNA Mismatch Repair in Lung Adenocarcinoma in Morocco

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A study was conducted to evaluate the mismatch repair (MMR) status of primary lung adenocarcinoma in Morocco. The researchers analyzed 28 samples of primary lung adenocarcinoma and found that microsatellite instability (MSI-H) was very rare in these cases. The majority of the cases were diagnosed at a locally advanced or metastatic stage, and most of the patients were smokers. All adenocarcinomas were positive for cytokeratin 7 (CK7) and thyroid transcription factor-1 (TTF-1), and negative for p40, p63, CK5/6, and CK20. Microsatellite analysis was performed on all tumors using immunohistochemistry to detect the presence or absence of proteins involved in the MMR pathway (MSH2, MSH6, MLH1, and PMS2). Only one out of the 28 lung adenocarcinomas analyzed showed MSI-H. The researchers concluded that more studies on larger series are needed to confirm these findings. Understanding microsatellite instability may lead to new therapeutic opportunities and warrant further investigation.

Asset Subtitle

Ouassima Erefai

Meta Tag

Speaker Ouassima Erefai

Topic Tumour Biology and Biomarkers - Tumour Biology & Preclinical Studies

Keywords

study

mismatch repair

MMR

primary lung adenocarcinoma

Morocco

microsatellite instability

MSI-H

locally advanced

metastatic stage

smokers