2022 World Conference on Lung Cancer (ePosters)-EP16.04-020. Dysregulation of 14-3-3 Signaling Adapters in Lung Adenocarcinoma, New Insights Into the Impact on Cancer Cell Biology

EP16.04-020. Dysregulation of 14-3-3 Signaling Adapters in Lung Adenocarcinoma, New Insights Into the Impact on Cancer Cell Biology

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A study conducted by researchers at the Centre for Cancer Biology in Australia explored the dysregulation of 14-3-3 signaling adapters in lung adenocarcinoma (LUAD) and its impact on cancer cell biology. The researchers utilized various methods including meta-analysis of transcriptomic and genomic data, analysis of proteomic data, tissue microarray analysis, and genetic alteration of LUAD cell lines.<br /><br />The results of the study showed that the 14-3-3 genes were significantly dysregulated in LUAD tissue, with increased expression associated with poor overall survival. The 14-3-3Zeta gene was amplified in a small subset of LUAD samples, while the 14-3-3Epsilon gene was lost in a small subset of samples. The protein abundance of 14-3-3 isoforms was also found to be altered in LUAD tissue.<br /><br />Furthermore, the study found that modulation of 14-3-3Zeta and Epsilon had opposing effects on focal adhesion signaling in LUAD cells. Loss of 14-3-3Epsilon in LUAD may contribute to a more aggressive cancer phenotype.<br /><br />Overall, the study highlights the importance of understanding the dysregulation of 14-3-3 signaling adapters in LUAD and its impact on cancer cell biology. These findings may lead to the identification of potential therapeutic targets for the treatment of LUAD and overcoming acquired resistance to targeted therapies.

Asset Subtitle

Rhys Hamon

Meta Tag

Speaker Rhys Hamon

Topic Tumour Biology and Biomarkers - Tumour Biology & Preclinical Studies

Keywords

14-3-3 signaling adapters

lung adenocarcinoma

LUAD

cancer cell biology

transcriptomic data

proteomic data

genetic alteration

overall survival

focal adhesion signaling

therapeutic targets