2022 World Conference on Lung Cancer (ePosters)-EP16.04-025. Statins Suppress SOAT1 Expression & Reduce Cholesterol Esterification in Statin-sensitive Lung Cancer Cells

EP16.04-025. Statins Suppress SOAT1 Expression & Reduce Cholesterol Esterification in Statin-sensitive Lung Cancer Cells

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Researchers have conducted a study to examine the effects of statin treatment on cholesterol synthesis-related factors in lung cancer cells. The study focused on comparing the responses of statin-sensitive HOP-92 cells and statin-resistant NCI-H322M cells using comprehensive transcriptome analyses.<br /><br />The results showed that the expression of certain genes involved in coenzyme A (CoA) metabolism, specifically acetyl-CoA acetyltransferase 1 (ACAT1) and pantothenate kinase 2 (PANK2), were downregulated in statin-sensitive cells. Additionally, the levels of hydroxymethylglutaryl-CoA (HMG-CoA) and CoA, which are metabolites related to CoA, were lower in statin-sensitive cells compared to statin-resistant cells.<br /><br />Furthermore, the study found that the gene SOAT1, involved in cholesterol esterification, was downregulated in statin-sensitive cancer cells. This was consistent with the decrease in total cholesterol and cholesterol ester levels observed in statin-sensitive cells treated with atorvastatin, while the same dosage did not affect the levels in statin-resistant cells.<br /><br />The researchers suggest that the downregulation of ACAT1, PANK2, and SOAT1 in statin-sensitive cells may contribute to the anti-cancer effect of statins. In particular, the reduction in esterified cholesterol, the intracellular storage form of cholesterol, through downregulation of SOAT1 may enhance the effectiveness of statins in statin-sensitive cancer cells.<br /><br />Overall, this study provides insights into the molecular mechanisms underlying the anti-cancer effects of statins in lung cancer cells. It highlights the importance of understanding the specific characteristics of cancer cells in order to develop more targeted therapeutic approaches.

Asset Subtitle

Katsuhiko Warita

Meta Tag

Speaker Katsuhiko Warita

Topic Tumour Biology and Biomarkers - Tumour Biology & Preclinical Studies

Keywords

statin treatment

cholesterol synthesis

lung cancer cells

statin-sensitive cells

statin-resistant cells

ACAT1

PANK2

HMG-CoA

SOAT1

anti-cancer effect