2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.001 Margaret Locke Abstract

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A study was conducted to evaluate the histopathological features of stage I non-small cell lung cancer (NSCLC) and their correlation with outcomes. The study included 597 patients who underwent lung resection for stage I NSCLC between 2015-2019. Patients with neoadjuvant chemotherapy or higher stage cancers were excluded. The patients' medical records were reviewed for various factors, including demographics, smoking history, histopathological features, TNM staging, recurrence, and death.<br /><br />The results showed that lymphovascular invasion (LVI) was a strong independent predictor of shorter recurrence-free survival (RFS) in stage I NSCLC. Other histopathological features such as visceral pleural invasion (VPI), spread through airspaces (STAS), and micropapillary pattern did not have a significant association with RFS. LVI was found in 33 patients, VPI in 47 patients, STAS in 38 patients, perineural invasion in 1 patient, and micropapillary involvement in 75 patients.<br /><br />The study concluded that LVI and other histopathological features can be powerful tools in the risk stratification of early-stage lung cancers. The findings suggest that identifying the presence of LVI in stage I NSCLC could help predict the likelihood of recurrence after surgery. This information can be valuable in determining the most appropriate management and treatment strategies for patients with early-stage NSCLC.<br /><br />Overall, this study highlights the importance of considering histopathological features in the evaluation and management of stage I NSCLC. Understanding the risk factors associated with recurrence can help improve patient outcomes by guiding treatment decisions and postoperative surveillance. Further research is warranted to validate these findings and explore additional histopathological correlates that may contribute to the prognosis of NSCLC.

Asset Subtitle

Margaret Locke

Keywords

histopathological features

stage I NSCLC

outcomes

lung resection

recurrence-free survival

lymphovascular invasion

visceral pleural invasion

spread through airspaces

micropapillary pattern

risk stratification