2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.01 (Poster) High-risk histopathological correlates of stage I non-small cell lung cancer (NSCLC) outcomes

PP01.01 (Poster) High-risk histopathological correlates of stage I non-small cell lung cancer (NSCLC) outcomes

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The study aimed to evaluate the correlation between certain high-risk histopathological features and patient outcomes in stage 1 non-small cell lung cancer (NSCLC). The researchers conducted a retrospective chart review of patients who underwent lung resection for NSCLC between 2015-2019 at a single academic center. A total of 597 patients were included in the final analysis.<br /><br />The mean age at diagnosis was 69.9 years, with 62.3% being female. The majority of patients were smokers (71.7%) and had adenocarcinoma (82.7%). The median Charlson Comorbidity Index was 6. During follow-up, 44 patients (7.3%) experienced recurrence.<br /><br />The main finding of the study was that lymphovascular invasion (LVI) was an independent predictor for shorter recurrence-free survival (RFS). Patients with LVI had a higher risk of recurrence compared to those without LVI. In contrast, visceral pleural invasion (VPI), which is currently recognized in the 8th edition guidelines for staging NSCLC, was not statistically significant in predicting patient outcomes in this study.<br /><br />The researchers suggested that LVI, along with other histopathological features, could be useful for risk stratification of early-stage lung cancers. They also acknowledged the limitations of their study, including its retrospective nature, small sample size, and potential confounders not being assessed.<br /><br />In conclusion, the study highlighted the importance of LVI as a strong independent predictor of recurrence in stage 1 NSCLC. The researchers recommended further research to determine if LVI presence should prompt more aggressive treatment. Overall, histopathological features can be valuable tools in risk stratification for early-stage lung cancers.

Asset Subtitle

Margaret Locke

Keywords

correlation

high-risk histopathological features

patient outcomes

stage 1 non-small cell lung cancer

retrospective chart review

recurrence

lymphovascular invasion

visceral pleural invasion

risk stratification

early-stage lung cancers