2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.047 Palina Woodhouse NACLC23 Abstract

PP01.047 Palina Woodhouse NACLC23 Abstract

Pdf Summary

Researchers at Vanderbilt University Medical Center have developed a web-based calculator called TREAT 2.0 to assess the risk of malignancy in patients with indeterminate pulmonary nodules (IPNs). The calculator aims to improve upon existing risk calculators that lack the discrimination needed for clinical use. <br /><br />The TREAT 2.0 model was developed using data from a cohort of 1,401 patients with IPNs. The researchers identified 13 variables that accurately estimated the risk of malignancy in high cancer prevalence settings. In order to create a web-based calculator, the researchers sought to identify a minimum set of variables that could achieve accurate risk estimation.<br /><br />By analyzing the data, the researchers found that age, pack-years (a measure of smoking history), and the clinical setting of evaluation were the most influential variables in improving the accuracy of the model. They identified a minimum three-variable set that had improved area under the receiver operating curve (AUC) compared to other risk calculators.<br /><br />The TREAT 2.0 calculator allows clinicians to receive a risk score that reflects the high-risk population evaluated in lung nodule clinics. It also allows for the use of incomplete input of the 13 variables, making it more practical for clinical use. The use of this calculator could potentially reduce the time to diagnosis for cancer and unnecessary surgeries for benign nodules.<br /><br />Overall, the researchers have developed a web-based lung nodule calculator that improves clinical risk prediction and provides clinicians with a more accurate assessment of malignancy risk in patients with IPNs. This tool has the potential to improve patient outcomes by guiding appropriate management decisions.

Keywords

Vanderbilt University Medical Center

TREAT 2.0

malignancy risk assessment

indeterminate pulmonary nodules

web-based calculator

risk calculators

clinical use

cancer prevalence settings

age

pack-years