2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.052 Tyler Faith NACLC23 Abstract

PP01.052 Tyler Faith NACLC23 Abstract

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A retrospective NGS study was conducted to explore the effect of altered RNA expression on tumor immune infiltration in non-small cell lung cancer (NSCLC). The researchers hypothesized that changes in RNA expression could impact immune infiltration in NSCLC and potentially guide biomarker development. The study involved reviewing RNA transcriptomic profile reports of NSCLC patients and analyzing tumor biopsies using RNA sequencing. The profile reports included immune infiltration scores predicted using a machine-learning model trained on mRNA expression and pathologist-scored IHC data. <br /><br />In the study, 144 NSCLC tumor samples were examined. The results revealed significant differences in average total immune infiltration and average adjusted immune infiltration based on altered RNA expression for several genes. Specifically, samples with overexpression of BRAF, HRAS, and PDGFRB showed reduced immune infiltration compared to samples with normal expression levels. On the other hand, samples with underexpression of CDKN2B had increased immune infiltration. <br /><br />The findings of this study suggest that altered RNA expression may impact the level of immune infiltration in NSCLC. However, further research is needed to understand the effect of RNA expression and immune infiltration on the response to immunotherapy and overall survival in NSCLC patients. The study highlights the potential importance of considering RNA expression patterns in developing biomarkers for NSCLC treatment.

Keywords

retrospective NGS study

altered RNA expression

tumor immune infiltration

NSCLC

biomarker development

RNA sequencing

immune infiltration scores

mRNA expression

NSCLC tumor samples

immunotherapy response