2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.110 (Poster) The Relationship Between Social Determinants of Health and Treatment Patterns and Outcomes in Patients with Metastatic Non-Small Cell Lung Cancer

PP01.110 (Poster) The Relationship Between Social Determinants of Health and Treatment Patterns and Outcomes in Patients with Metastatic Non-Small Cell Lung Cancer

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This study aimed to evaluate the relationship between social determinants of health (SDOH), treatment patterns, and outcomes in patients with metastatic non-small cell lung cancer (NSCLC). The study used electronic medical records (EMR) linked to commercial claims data to analyze patient data.<br /><br />The study included 869 patients, with 290 receiving IO chemotherapy, 149 receiving chemotherapy, 132 receiving IO other treatments, and 94 receiving other medications. In total, 204 patients did not receive any systemic treatment after the index date.<br /><br />The analysis of demographic characteristics showed that the median age of patients was 67 years, with 75.1% of patients under the age of 75. The gender distribution was 46.6% male and 53.4% female. The majority of patients had insurance through PPO (34.9%) or HMO (15.1%). Geographic distribution showed that the highest proportion of patients were in the Midwest (41.1%) region.<br /><br />The study found that race appeared to impact first-line treatment among patients with metastatic NSCLC. Black patients had a longer time to receipt of first-line therapy and were less likely to receive any IO therapy compared to White patients. Black patients also had a shorter overall survival, although this finding was not statistically significant.<br /><br />There was also an observed trend towards a greater likelihood of receipt of IO therapy for patients living in neighborhoods with a higher socioeconomic status index score, although this was not statistically significant.<br /><br />The study has several limitations, including the use of only commercial claims data, potential selection bias, and possible data incompleteness. The small sample size may also impact the interpretation of the results.<br /><br />The study highlights the need for further exploration to identify the unmet needs of Black patients and patients with lower socioeconomic status. The findings suggest that social determinants of health may play a role in treatment patterns and outcomes for patients with metastatic NSCLC.

Asset Subtitle

Umit Tapan

Keywords

social determinants of health

treatment patterns

outcomes

metastatic non-small cell lung cancer

electronic medical records

commercial claims data

IO chemotherapy

demographic characteristics

first-line treatment

socioeconomic status