2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.127 (Poster) A rare case of pulmonary enteric adenocarcinoma in a 26-year-old female non-smoker

PP01.127 (Poster) A rare case of pulmonary enteric adenocarcinoma in a 26-year-old female non-smoker

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A 26-year-old female non-smoker presented with a chronic cough and abnormal CT chest findings initially concerning for tuberculosis. Despite treatment for presumed infection, her symptoms persisted, and she experienced significant weight loss. Biopsy results ultimately revealed a rare subtype of non-small cell lung cancer called pulmonary enteric adenocarcinoma (PEAC), which is typically seen in older smoking males. This case is uncommon due to the patient's young age, multifocal appearance of the disease, and delayed diagnosis. PEAC is thought to develop from abnormal embryologic differentiation of the foregut into the lungs and gastrointestinal/hepatobiliary tract. Molecular testing played a crucial role in confirming the diagnosis and understanding the nature of PEAC. Unfortunately, the patient's condition deteriorated rapidly, and she developed complications such as venous thromboembolisms and respiratory distress. Despite chemotherapy treatment, her disease progressed, and she passed away from multi-organ failure. This case highlights the need for further research and understanding of PEAC, as knowledge about its pathology and management is currently limited. The use of molecular testing can help identify the true at-risk population for this rare form of lung cancer.

Asset Subtitle

Shruti Gupta

Keywords

non-smoker

chronic cough

abnormal CT chest findings

pulmonary enteric adenocarcinoma

young age

delayed diagnosis

molecular testing

respiratory distress

chemotherapy treatment

rare lung cancer