2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.134 (Poster) Pathologist Driven Reflex Testing Provides Rapid, Orthogonal Results to NSCLC Patients in Response to Comprehensive Genomic Profiling QNS

PP01.134 (Poster) Pathologist Driven Reflex Testing Provides Rapid, Orthogonal Results to NSCLC Patients in Response to Comprehensive Genomic Profiling QNS

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PathGroup, a comprehensive laboratory services provider specializing in pathology services, conducted a study on the use of pathologist-driven reflex testing in providing timely results for non-small cell lung cancer (NSCLC) patients who had insufficient tissue for comprehensive genomic profiling (CGP) testing.<br /><br />The study showed that a significant number of NSCLC patient samples (573) were rendered insufficient for CGP testing at various stages. However, with reflex testing methods, 51.5% of these patients were able to obtain results from single gene testing or fluorescence in situ hybridization (FISH) testing.<br /><br />The results were reported with a median turnaround time of 4 business days from the time of CGP insufficiency. Additionally, 80.3% of patients received immunohistochemistry (IHC) results for PD-L1 expression, an additional biomarker.<br /><br />PathGroup's ability to perform additional molecular testing modalities in their full-service pathology laboratory allowed for timely and clinically informative results for patients with insufficient tissue for CGP. This approach reduced the risk of morbidity and cost associated with repeat procedures.<br /><br />The study highlights the advantage of utilizing pathologist-driven testing algorithms in reflexively performing orthogonal molecular testing, maximizing tissue stewardship and providing rapid results. By repurposing tissue and DNA where possible, patients were able to obtain actionable results from alternative testing methods.<br /><br />The use of reflex testing alleviates the barrier posed by tissue quality and quantity requirements for CGP testing, ensuring that patients receive comprehensive genomic profiling and appropriate treatment decisions. The study supports the National Comprehensive Cancer Network (NCCN) guidelines that advocate for CGP as the standard of care for detecting genomic alterations in advanced stage NSCLC.<br /><br />Overall, the findings demonstrate the effectiveness of pathologist-driven reflex testing in providing timely and informative results for NSCLC patients with insufficient tissue for CGP, ultimately leading to better patient outcomes.

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Michelle Shiller

Keywords

PathGroup

laboratory services

pathology services

reflex testing

non-small cell lung cancer

NSCLC

comprehensive genomic profiling

CGP testing

molecular testing

tissue stewardship