2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.140 (Poster) Patient Preferences for EGFRExon 20 Insertion-Targeted Therapies in NSCLC: A Multi-Dimensional Thresholding Analysis

PP01.140 (Poster) Patient Preferences for EGFRExon 20 Insertion-Targeted Therapies in NSCLC: A Multi-Dimensional Thresholding Analysis

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A study was conducted to determine patient preferences for EGFR exon 20 insertion-targeted therapies in non-small cell lung cancer (NSCLC) and their willingness to accept treatment-related risks. The study included 167 participants with locally advanced or metastatic NSCLC harboring EGFR exon 20 insertions or other EGFR mutations. The participants completed an online survey that consisted of ranking treatment regimen options and evaluating treatment-related attributes through thresholding exercises.<br /><br />The results showed that most participants preferred a daily oral pill over IV infusions. Participants were willing to forgo up to 9-12% of the disease control rate (DCR) to switch from IV infusions to an oral pill. They were also willing to accept increased risks of severe diarrhea, fatigue, rash, or nausea/vomiting to switch from IV infusions to an oral pill.<br /><br />Improving DCR was the most valued treatment attribute, but participants were willing to sacrifice some benefit in favor of a preferred regimen, which was mostly the oral pill. The study found that patients highly value efficacy but also consider treatment-related attributes such as side effects and route of drug administration in their preferences.<br /><br />The analysis also revealed that willingness to accept the loss of DCR varied based on personal characteristics, such as health status, time since diagnosis, gender, and age. However, there was limited variation in the importance of other attributes.<br /><br />The study has some limitations, including potential information bias and differences in participant characteristics based on recruitment approaches. However, the findings provide insights into patient preferences and can contribute to shared decision-making in the treatment of NSCLC.<br /><br />Overall, the study highlights the importance of considering patient preferences and treatment-related attributes in patient-centered care for NSCLC.

Asset Subtitle

Jun Zhang

Keywords

patient preferences

EGFR exon 20 insertion-targeted therapies

NSCLC

treatment-related risks

oral pill

IV infusions

disease control rate

side effects

personal characteristics

shared decision-making