2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.36 (Poster) Applying a Lung Cancer Screening Model on a Real-World Population

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This reference document provides information on lung cancer screening criteria and performance metrics for different cohorts. The study compares the criteria used by the National Lung Screening Trial (NLST) and the U.S. Preventive Services Task Force (USPSTF) for selecting individuals for lung cancer screening.<br /><br />The NLST criteria include an age range of 55-74 years, a smoking quit time of 15 years, and a history of at least 30 pack-years of smoking. On the other hand, the USPSTF criteria include an age range of 50-80 years, a smoking quit time of 15 years, and a history of at least 20 pack-years of smoking.<br /><br />The performance metrics for the NLST and UCLA cohorts were evaluated using sensitivity, specificity, precision, and the area under the receiver operating characteristic (ROC) curve and precision-recall (PR) curve. The results showed that both the NLST and USPSTF criteria had similar performance in terms of sensitivity, specificity, and precision for both the NLST and UCLA cohorts.<br /><br />The study also compared various demographic and clinical characteristics between the NLST and UCLA cohorts under the NLST and USPSTF criteria. These characteristics included factors such as age, body mass index (BMI), smoking history, presence of chronic obstructive pulmonary disease (COPD), family history of lung cancer, personal history of cancer, educational level, and race/ethnicity.<br /><br />Overall, the study provides insights into the selection criteria and performance of lung cancer screening programs, highlighting the importance of considering various factors when determining eligibility for screening. The findings can contribute to improving screening strategies and optimizing the identification of individuals at high risk of lung cancer.

Asset Subtitle

Warren Coons

Keywords

lung cancer screening

criteria

performance metrics

NLST

USPSTF

age range

smoking quit time

pack-years of smoking

sensitivity

specificity