2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.47 (Poster) TREAT 2.0 – Creation of a Clinically Useful High-Risk Lung Nodule Calculator

PP01.47 (Poster) TREAT 2.0 – Creation of a Clinically Useful High-Risk Lung Nodule Calculator

Pdf Summary

Researchers from Vanderbilt University Medical Center have developed a web-based calculator that can accurately estimate the risk of malignancy in indeterminate pulmonary nodules (IPNs). IPNs are common and require risk stratification, but existing risk calculators lack accuracy. The new calculator, called TREAT 2.0, was developed using data from a cohort of 1,401 patients with IPNs. It includes 13 variables such as age, gender, smoking pack-years, nodule size, and PET avidity. The researchers used a pattern submodel approach to account for missing data, creating multiple logistic regression models for different combinations of missing variables. They validated the accuracy and discriminative ability of each submodel using cross-validation and compared them to existing risk models. The results showed that TREAT 2.0 outperformed other models in terms of predictive accuracy and discriminative ability. The web-based format of the calculator makes it easy for clinicians to use in their practice. The researchers believe that the improved accuracy of TREAT 2.0 will lead to increased use of predictive models in IPN diagnostic decision-making. The study was supported by the National Cancer Institute.

Asset Subtitle

Palina Woodhouse

Keywords

Vanderbilt University Medical Center

web-based calculator

malignancy risk estimation

indeterminate pulmonary nodules

IPNs

TREAT 2.0

logistic regression models

predictive accuracy

discriminative ability

diagnostic decision-making