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2023 North America Conference on Lung Cancer (NACL ...
PP01.52 (Poster) The Effect of Altered RNA Express ...
PP01.52 (Poster) The Effect of Altered RNA Expression on Tumor Immune Infiltration in NSCLC: A Retrospective NGS Study
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Pdf Summary
A retrospective study was conducted to investigate the impact of altered RNA expression on tumor immune infiltration in patients with non-small cell lung cancer (NSCLC). The study utilized RNA transcriptome profile reports and immune infiltration scores from 144 NSCLC patients at UI Health. The patients' tumor biopsies underwent whole exome capture RNA sequencing, and machine-learning models were used to predict immune infiltration scores based on mRNA expression and immunohistochemistry data.<br /><br />The results showed significant differences in both average total immune infiltration and average adjusted immune infiltration based on altered RNA expression for several genes. Some genes, such as BRAF, HRAS, and PDGFRB, were associated with reduced immune infiltration, while others, like CDKN2B, were associated with increased immune infiltration.<br /><br />The study suggests that altered RNA expression may impact immune infiltration in NSCLC. Changes in certain genes inhibited immune infiltration, while changes in others promoted it. The study also found that specific immune cell populations were affected by the altered expression of certain genes.<br /><br />Further research is needed to investigate the relationship between RNA expression, immune infiltration, and response to immunotherapy in NSCLC patients. The findings of this study may contribute to the development of prognostic biomarkers for immunotherapy response and inform treatment decisions for NSCLC patients.
Asset Subtitle
Tyler Faith
Keywords
retrospective study
altered RNA expression
tumor immune infiltration
NSCLC
RNA transcriptome profile
immune infiltration scores
machine-learning models
BRAF
CDKN2B
response to immunotherapy
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