2023 North America Conference on Lung Cancer (NACLC) - Posters and Abstracts-PP01.70 (Poster) Next Generation of Bronchoscopy for Diagnostic Evaluation of Non-Small Cell Lung Cancer

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A recent study evaluated the effectiveness of robotic-assisted bronchoscopy (RB) in obtaining tissue samples for next generation sequencing (NGS) analysis in patients with non-small cell lung cancer (NSCLC). Targeted immunotherapy has become a valuable treatment option for NSCLC, and NGS analysis plays a crucial role in identifying potential therapeutic targets. The researchers aimed to determine the adequacy of tissue samples obtained through RB for NGS analysis.<br /><br />The study included patients who underwent RB for evaluation of peripheral lung nodules at a single center. For confirmed cases of NSCLC, genomic profiling and programmed death-ligand 1 (PD-L1) testing were performed. The researchers assessed the tissue cellularity for NGS analysis and the presence of actionable mutations.<br /><br />The results showed that approximately 70% of the lesions evaluated through RB were diagnostic, and 88% of the cases were sufficient for NGS analysis. In addition, a combination of RB and endobronchial ultrasound (EBUS) performed under one anesthesia event was able to provide full staging in 80.5% of patients. However, the study had limitations, including a small sample size and being conducted at a single center.<br /><br />The findings suggest that RB can be an effective diagnostic tool for obtaining tissue samples for NGS analysis in NSCLC patients. The ability of RB to assist with navigation to peripheral lung nodules without compromising diagnostic yield and the potential to obtain sufficient tissue for targeted therapy in a single procedure make it an attractive option.<br /><br />In conclusion, RB shows promise as a next generation bronchoscopy technique for the diagnostic evaluation of NSCLC. Further research with larger sample sizes and multi-center studies is warranted to validate these findings and optimize the use of RB in guiding treatment management for NSCLC.

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Sylvia Yong

Keywords

robotic-assisted bronchoscopy

next generation sequencing

non-small cell lung cancer

targeted immunotherapy

genomic profiling

programmed death-ligand 1

tissue cellularity

actionable mutations

endobronchial ultrasound

diagnostic evaluation