2023 Targeted Therapies of Lung Cancer Meeting (Poster)-P1.06. Real World Outcomes of Lurbinectedin as Second Line Treatment in Extensive Stage-Small Cell Lung Cancer (ES-SCLC)

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Researchers from the Mayo Clinic in Rochester, Minnesota, conducted a study to evaluate the real-world outcomes of using lurbinectedin as a second-line treatment in patients with extensive stage-small cell lung cancer (ES-SCLC). The study included 50 patients who received lurbinectedin between June 2020 and June 2022.<br /><br />The baseline characteristics of the patients showed that the median age at diagnosis was 67 years, with 50% of the patients being female. The median follow-up from diagnosis and initiation of treatment was 13.3 and 5 months, respectively. The majority of patients (94%) had de novo SCLC, while a small percentage (6%) had SCLC transformed from non-small cell lung cancer (NSCLC). Eighty-two percent of patients had ES-SCLC at diagnosis.<br /><br />The median number of cycles of lurbinectedin received by the patients was 3, with most receiving the standard dose of 3.2 mg/m2. Twelve patients (24%) received a dose reduction due to previous myelosuppression, fatigue, or frailty. The median chemotherapy-free interval (CTFI) among the cohort was 74 days.<br /><br />Grade 3 or higher adverse events reported included neutropenia, anemia, thrombocytopenia, and elevated ALT, each occurring in 6% of patients. Twelve percent of patients required dose reduction due to myelosuppression or fatigue. Growth factor support was given to 20% of patients.<br /><br />The study found that there were no grade 5 toxicities associated with lurbinectedin at the standard dose. The median progression-free survival (PFS) for the cohort was 2.08 months, and the median overall survival (OS) was 5.1 months.<br /><br />In conclusion, the study showed that lurbinectedin was generally well-tolerated as a second-line treatment for relapsed/refractory ES-SCLC. However, the real-world outcomes remain suboptimal, highlighting the need for improved treatment strategies for patients with SCLC.

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Aakash Desai, Mayo Clinic, United States

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Speaker Aakash Desai, Mayo Clinic, United States

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Keywords

Mayo Clinic

Rochester

Minnesota

lurbinectedin

second-line treatment

extensive stage-small cell lung cancer

ES-SCLC

patients

real-world outcomes

study