2023 Targeted Therapies of Lung Cancer Meeting (Poster)-P1.27. Clinicogenomic Characteristics of EGFR-Mutant Non-Small Cell Lung Carcinoma with CNS Metastases

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This study aimed to assess the clinicogenomic characteristics and outcomes of patients with EGFR-mutant non-small cell lung carcinoma (NSCLC) and central nervous system (CNS) metastases. The researchers conducted a retrospective analysis of patients with EGFR-mutant NSCLC and available CNS tumor samples that underwent next-generation sequencing. They obtained clinical characteristics and outcome data from the hospital's electronic database.<br /><br />The study found that leptomeningeal carcinomatosis (LM) was present in 52 patients, while 38 patients had brain metastases (BrM) only. The median age of the patients was 59, and the majority were female and white. The study also looked at smoking history and found that the majority of patients were never smokers.<br /><br />In terms of baseline CNS metastases, 36 patients had de novo metastases, 15 had metastases while on treatment, and 1 had an unknown status. The study also examined the histology of the tumors and found that adenocarcinoma was the most common type. The study identified EGFR alterations, with exon 19 del being the most common alteration.<br /><br />The study also analyzed concurrent alterations and found that TP53 alterations were present in a significant number of patients. The researchers looked at the use of radiation therapy and found that the majority of patients had received radiation.<br /><br />Furthermore, the study identified specific genetic alterations associated with brain metastases. RAC1, MET, and CARD11 were found to be significantly associated with brain metastases. Moreover, the study identified genetic alterations in paired samples of systemic and CNS tumors.<br /><br />In conclusion, this study provides valuable insights into the clinicogenomic characteristics of EGFR-mutant NSCLC patients with CNS metastases. It highlights the need for further research to explore the role of specific genetic alterations in the development of CNS metastases.

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Jane Sze Yin Sui, Memorial Sloan Kettering Cancer Center, United States

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Speaker Jane Sze Yin Sui, Memorial Sloan Kettering Cancer Center, United States

Topic Poster Listing

Keywords

clinicogenomic characteristics

EGFR-mutant NSCLC

CNS metastases

retrospective analysis

leptomeningeal carcinomatosis

brain metastases

smoking history

baseline CNS metastases

genetic alterations

radiation therapy