2023 World Conference on Lung Cancer (Posters)-EP01.01. Genomic Alterations of Lung Cancer: Experience in Peru

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This presentation discusses the genomic alterations of lung cancer in Peru. The study aimed to describe the mutational landscape of lung cancer patients in the country. The researchers conducted a cross-sectional evaluation of 134 lung cancer patients who underwent molecular profiling using various platforms. <br /><br />The results showed that 90.3% of the patients had non-small cell lung cancer (NSCLC) adenocarcinomas, 6.7% had NSCLC squamous carcinoma, and 3.0% had small cell lung cancer. Among the patients, 67.9% were women and 15.7% were smokers. Genetic alterations were identified in 52.2% of the patients, with the most frequent alterations in the genes EGFR, ALK, MET, and DNMT3A. <br /><br />Among the patients who underwent comprehensive molecular profiling, 72.2% had at least one genetic alteration, with EGFR mutation being the most common alteration. Next generation sequencing revealed co-mutations, with TP53, CDKN2A/B, and STK11 being the most frequently co-mutated genes. Dual mutations in EGFR were also found in this population. <br /><br />The study highlights the real-world disparity in access to comprehensive molecular profiling tests among the Peruvian population. It suggests that next generation sequencing is superior to other testing methods in detecting relevant mutations and co-mutations for the clinical management of lung cancer patients. The findings emphasize the need for early access to comprehensive molecular profiling. However, further validation with a larger population is necessary to confirm these findings. Overall, this study provides insights into the mutation and co-mutation landscape of lung cancer patients in Peru.

Asset Subtitle

George Oblitas

Meta Tag

Speaker George Oblitas

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

genomic alterations

lung cancer

Peru

mutational landscape

non-small cell lung cancer

adenocarcinomas

squamous carcinoma

small cell lung cancer

women

smokers