2023 World Conference on Lung Cancer (Posters)-EP02.01. DEPDC1 Expression and Mechanisms in Lung Adenocarcinoma : Insights into Proliferation and KIF2C Regulation

EP02.01. DEPDC1 Expression and Mechanisms in Lung Adenocarcinoma : Insights into Proliferation and KIF2C Regulation - PDF(Slides)

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The study conducted by Jun Wang and colleagues aimed to investigate the role of DEPDC1 in lung adenocarcinoma (LUAD) and its potential impact on proliferation and KIF2C regulation. The researchers analyzed the expression patterns of DEPDC1 in LUAD and normal tissues using bioinformatic techniques and found that DEPDC1 expression was significantly higher in LUAD tissues compared to normal tissues. This high expression was also associated with poor prognosis in LUAD patients. <br /><br />Further experiments were conducted in vitro using lung adenocarcinoma cell lines to explore the effects of DEPDC1 on proliferation. The results showed that DEPDC1 knockdown inhibited the proliferation, migration, and invasion of lung adenocarcinoma cells. Additionally, DEPDC1 knockdown inhibited the expression of mTOR pathway markers and their phosphorylation levels. <br /><br />The researchers also identified a regulatory axis where DEPDC1 regulates the growth of LUAD cells through KIF2C. Overexpression of KIF2C attenuated the inhibitory effects of DEPDC1 knockdown on proliferation, invasion, and migration of lung adenocarcinoma cells, as well as the inhibitory effects on mTOR pathway markers and their phosphorylation. <br /><br />The findings of this study highlight the significant role of DEPDC1 in LUAD tumorigenesis and provide potential targets for future therapeutic interventions. DEPDC1 may be involved in the modulation of the mTOR pathway and affects the proliferation, invasion, and migration of lung adenocarcinoma cells through KIF2C. These results contribute to a better understanding of the mechanisms underlying LUAD and may have implications for the development of targeted therapies.

Asset Subtitle

Sisi He

Meta Tag

Speaker Sisi He

Topic Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets

Keywords

DEPDC1

lung adenocarcinoma

LUAD

proliferation

KIF2C regulation

bioinformatic techniques

expression patterns

poor prognosis

mTOR pathway

therapeutic interventions