2023 World Conference on Lung Cancer (Posters)-EP02.01. PEG2000-PLA-Based Nanoscale Polymeric Micellar Reduces Paclitaxel-Related Toxicity in Beagles

EP02.01. PEG2000-PLA-Based Nanoscale Polymeric Micellar Reduces Paclitaxel-Related Toxicity in Beagles - PDF(Abstract)

Pdf Summary

This study explores the toxicological profiling of a nanoscale polymeric micellar (Pm) delivery system for paclitaxel in beagles. The researchers conducted acute toxicity tests, short-term toxicity tests, and long-term toxicity tests on a total of 27 beagles. The results showed that the lethal dosage of Pm-paclitaxel was found to be between 20-30 mg/kg in beagles, with the digestive system and immuno-hematopoietic system being the most affected. The short-term toxicity test indicated that the use of the Pm delivery system reduced paclitaxel-induced toxicities such as peripheral neuropathy, hemopoietic toxicity, and heart system toxicity in beagles. The long-term toxicity test further demonstrated that the Pm-paclitaxel delivery system also reduced hemopoietic toxicity in beagles. <br /><br />Overall, this study provides insights into the toxicological effects of the Pm-paclitaxel delivery system in beagles and suggests that it may serve as a promising clinical combination strategy in the future. The use of nanoplatform-based drug delivery, specifically the Pm delivery system, has the potential to decrease the toxicity of paclitaxel while maintaining its therapeutic efficacy. This research contributes to the understanding of the molecular therapeutic targets for paclitaxel and highlights the Beagle model as an effective tool in preclinical studies.

Asset Subtitle

Jun Lu

Meta Tag

Speaker Jun Lu

Topic Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets

Keywords

nanoscale polymeric micellar

Pm delivery system

paclitaxel

toxicological profiling

beagles

acute toxicity tests

short-term toxicity tests

long-term toxicity tests

lethal dosage

digestive system