2023 World Conference on Lung Cancer (Posters)-EP02.01. TP53 Mutation Has Significant Impact on Other Driver Genes in Lung Cancer

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In this study conducted by Yaxian Yang from Guangzhou Huayin Health Medical Group Co., Ltd in China, the researchers aimed to investigate the genetic characteristics of TP53, the most commonly mutated driver gene in cancer, and its impact on other driver genes in lung cancer. They collected 1,932 lung cancer tissue samples and used next-generation sequencing to obtain mutation information for TP53 and other genes.<br /><br />The results showed that 890 patients (46%) had TP53 mutations, and 1,114 patients (57%) had at least one EGFR mutation. TP53 mutations were found to significantly co-occur with CDKN2 and ARB1 mutations. However, TP53 mutations were mutually exclusive with most driver genes. The study also found that TP53 mutations had a significant impact on the mutation frequency of other driver genes and tumor mutational burden (TMB), suggesting that they may independently play a role in tumor development.<br /><br />Further analysis revealed that TP53 mutations were mutually exclusive with CDK4, BRCA2, ATM, and ALK mutations. On the other hand, EGFR mutations were only co-mutated with CTNNB1 and had no significant interaction with other genes. RB1 was identified as the most commonly associated mutated gene with TP53. Additionally, TP53 alterations exclusively co-occurred with EGFR, KRAS, and ALK mutations.<br /><br />The researchers classified the mutation types into four distinct patterns based on EGFR and TP53 status. Each pattern showed different mutations in most genes, with APC, PIK3CA, and ERBB2 being the most frequently mutated genes. Furthermore, the study found that TP53 mutations had a greater impact on TMB than EGFR mutations.<br /><br />In conclusion, the study provides insights into the genetic characteristics of TP53 mutations in lung cancer and their impact on other driver genes. The findings suggest that TP53 mutations play a significant role in tumor development and highlight the importance of assessing TP53 functions and implications in cancer research.

Asset Subtitle

Yaxian Yang

Meta Tag

Speaker Yaxian Yang

Topic Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets

Keywords

TP53

genetic characteristics

lung cancer

driver genes

mutation

next-generation sequencing

EGFR

CDKN2

ARB1

tumor mutational burden