2023 World Conference on Lung Cancer (Posters)-EP02.02. Microbiome in Lung Cancer: Culture-Based Analysis Using Transthoracic Needle Biopsy (TTNB)

EP02.02. Microbiome in Lung Cancer: Culture-Based Analysis Using Transthoracic Needle Biopsy (TTNB) - PDF(Abstract)

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This study explores the role of the microbiome in lung cancer by analyzing culture-based samples obtained through Transthoracic Needle Biopsy (TTNB). The human microbiome consists of bacteria, fungi, protozoa, and viruses that reside in the body. Previous studies have shown that the lung microbiome contributes to the development and progression of lung cancer, as well as the response to immunotherapy. However, there is limited information on the specific microbiome strains that are clinically relevant. <br /><br />In this study, the researchers analyzed 178 TTNB samples from patients with primary lung cancer. Cultures were performed on all samples, and the microbial organisms were identified in 25 cases. The most frequently identified organisms were Streptococcus, Staphylococcus, Klebsiella pneumonia, and Actinomyces. Other strains such as Bacillus, Chryseobacterium, Microbacterium, Rothia, and Serratia were also found. Most of the cultured microbiome strains were normal flora of the lung.<br /><br />Unfortunately, due to the small sample size and heterogeneity of cancer types and stages, no significant correlation was found between the cultured microorganisms and the overall survival or treatment response of lung cancer patients.<br /><br />The study successfully cultured microorganisms from TTNB tissue samples, minimizing the risk of contamination compared to other methods. The findings indirectly support the role of the microbiome in lung cancer biology. To further understand the microbiome in lung cancer, future studies should increase the sample size and utilize additional analysis methods such as rRNA gene analysis.<br /><br />This study provides evidence for the presence of microorganisms in lung cancer tissue and suggests the potential importance of the microbiome in lung cancer pathogenesis.

Asset Subtitle

So-yun Kim

Meta Tag

Speaker So-yun Kim

Topic Tumor Biology: Preclinical Biology - Omics Approaches

Keywords

microbiome

lung cancer

Transthoracic Needle Biopsy

bacteria

fungi

protozoa

viruses

lung microbiome

immunotherapy

microbial organisms