2023 World Conference on Lung Cancer (Posters)-EP02.02. Radiation-induced SERPINE2 Expression Inhibit Abscopal Effect in Non-small Cell Lung Cancer via Exosomes

EP02.02. Radiation-induced SERPINE2 Expression Inhibit Abscopal Effect in Non-small Cell Lung Cancer via Exosomes - PDF(Slides)

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A study conducted at Hangzhou Cancer Hospital in China aimed to investigate the non-target effect of radiation in non-small cell lung cancer (NSCLC) and its impact on the occurrence of the abscopal effect. The abscopal effect refers to the systemic anti-tumor effect of radiotherapy that extends beyond the treated area. The researchers used a co-culture system of lung cancer cells and xenografts to simulate the non-target effect, and found that irradiated lung cancer cells promoted the proliferation of unirradiated lung cancer cells. They identified the upregulation of the SERPINE2 gene in irradiated lung cancer cells and found that overexpression of SERPINE2 also promoted lung cancer cell proliferation and migration. They observed similar results in an in vivo study.<br /><br />Further analysis revealed that exosomes, small extracellular vesicles, released by SERPINE2 overexpressed lung cancer cells were absorbed by abscopal cells and promoted their proliferation. The researchers also identified the ERK/MAPK signaling pathway as being involved in the radiation-induced non-target effect. They found that the phosphorylation of ERK was a key step in this process.<br /><br />The study also established an in vitro abscopal model to better understand the phenomenon. They found that SERPINE2 exosomes promoted the migration and invasion of abscopal cells. Additionally, knockdown of SERPINE2 in SERPINE2 overexpressed lung cancer cells resulted in a decrease in migration and invasion.<br /><br />Overall, the study provides evidence of the radiation-induced non-target effect and its impact on the occurrence of the abscopal effect in NSCLC. The findings suggest that SERPINE2 plays a role in promoting the proliferation, migration, and invasion of abscopal cells, and that the ERK/MAPK signaling pathway is involved in this process. Understanding these mechanisms could potentially help improve the utilization of the systemic anti-tumor effect of radiotherapy.

Asset Subtitle

Lucheng Zhu

Meta Tag

Speaker Lucheng Zhu

Topic Tumor Biology: Preclinical Biology - Omics Approaches

Keywords

Hangzhou Cancer Hospital

China

non-small cell lung cancer

NSCLC

abscopal effect

radiation

co-culture system

SERPINE2 gene

exosomes

ERK/MAPK signaling pathway