2023 World Conference on Lung Cancer (Posters)-EP02.02. Transcriptomic Response to Tumor Treating Fields (TTFields) Across Tumor Types

EP02.02. Transcriptomic Response to Tumor Treating Fields (TTFields) Across Tumor Types - PDF(Abstract)

Pdf Summary

This study aimed to identify common responses to Tumor Treating Fields (TTFields) in different tumor types by analyzing gene expression patterns. TTFields are electric fields that disrupt processes essential for cancer cell viability and tumor progression. The researchers analyzed cells from various cancer types, including gastric, ovarian, pancreatic, non-small cell lung carcinoma, glioblastoma, and pleural mesothelioma. <br /><br />The analysis revealed a positive expression correlation across different cell lines in response to TTFields. Pathways related to the cell cycle, such as E2F targets, Myc targets, G2M checkpoint, and mitotic spindle, were downregulated, indicating cell cycle arrest through increased expression of tumor suppressors. Several DNA repair pathways, including nucleotide excision repair, base excision repair, and the Fanconi Anemia-BRCA pathway, were also downregulated. Other downregulated pathways included nuclear envelope, DNA and RNA synthesis, translation, splicing, metabolism of amino acids, and organelle organization. On the other hand, genes associated with the cytoskeleton, adhesion, extracellular proteins, transporters, and immune response showed upregulation in most comparisons.<br /><br />The findings suggest that TTFields induce coordinated responses in different tumor types. The study identified pathways that have been previously demonstrated and discovered new potential mechanisms involved in the response to TTFields. This transcriptomic analysis provides insights into the cellular responses to TTFields, contributing to a better understanding of the effects of this therapeutic approach.

Asset Subtitle

Moshe Giladi

Meta Tag

Speaker Moshe Giladi

Topic Tumor Biology: Preclinical Biology - Omics Approaches

Keywords

Tumor Treating Fields

gene expression patterns

cancer cell viability

tumor progression

cell cycle arrest

DNA repair pathways

cytoskeleton

immune response

transcriptomic analysis

therapeutic approach