2023 World Conference on Lung Cancer (Posters)-EP02.03. Circular RNA-mediated ceRNA Network was Indentified in Human Lung Adenocarcinoma by High-throughput Sequencing

EP02.03. Circular RNA-mediated ceRNA Network was Indentified in Human Lung Adenocarcinoma by High-throughput Sequencing - PDF(Abstract)

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This study investigated the expression profile of circular RNA (circRNA) in lung adenocarcinoma (LUAD) and its potential as biomarkers for diagnosis. 14 pairs of postoperative LUAD specimens were analyzed using second-generation sequencing, resulting in the identification of 18 dysregulated circRNAs in the LUAD tissues. Among these, four circRNAs showed upregulation and 14 circRNAs showed downregulation. Further analysis suggested that hsa_circ_0120106, has_circ_0007342, has_circ_0005937, and circRNA_0000826 could be potential biomarkers for the diagnosis of LUAD. Additionally, the study revealed interactions between the dysregulated circRNAs and several cancer-related miRNAs, and key putative pathways in LUAD were identified, including cell cycle phases transition, p53 signaling pathway, and AMPK signaling pathway. These findings suggest a correlation between abnormal circRNA expression and LUAD, highlighting the potential of circRNAs as diagnostic biomarkers for LUAD.

Asset Subtitle

wenmei su

Meta Tag

Speaker wenmei su

Topic Tumor Biology: Preclinical Biology - Regulatory Mechanisms

Keywords

circular RNA

lung adenocarcinoma

biomarkers

diagnosis

second-generation sequencing

dysregulated circRNAs

upregulation

downregulation

cancer-related miRNAs

putative pathways