2023 World Conference on Lung Cancer (Posters)-EP02.03. LINC00629 Regulates Cell Proliferation, Migration, Invasion and Apoptosis of Lung Adenocarcinoma

EP02.03. LINC00629 Regulates Cell Proliferation, Migration, Invasion and Apoptosis of Lung Adenocarcinoma - PDF(Slides)

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This study investigates the role of the long noncoding RNA (lncRNA) LINC00629 in the progression of lung adenocarcinoma (LUAD). The researchers found that LINC00629 is significantly upregulated in both LUAD tissues and cell lines. They then used lentivirus infection to knock down LINC00629 in LUAD cells, which resulted in a significant inhibition of cell proliferation, migration, and invasion, as well as promotion of apoptosis.<br /><br />Further analysis showed that LINC00629 regulates LUAD progression via the Wnt/β-catenin pathway. Knockdown of LINC00629 suppressed the protein expression of β-catenin, a key component of the Wnt signaling pathway. In addition, treatment with the Wnt/β-catenin agonist SKL2001 reversed the inhibitory effects of LINC00629 knockdown on cell proliferation, migration, invasion, and apoptosis.<br /><br />The researchers also conducted in vivo experiments and found that LINC00629 knockdown suppressed tumor growth in LUAD.<br /><br />Overall, these findings suggest that LINC00629 plays a significant role in the progression of LUAD by regulating cell proliferation, migration, invasion, and apoptosis through the Wnt/β-catenin pathway. This study provides potential insights into the development of therapeutic strategies targeting lncRNAs for LUAD.

Asset Subtitle

Sisi He

Meta Tag

Speaker Sisi He

Topic Tumor Biology: Preclinical Biology - Regulatory Mechanisms

Keywords

long noncoding RNA

LINC00629

lung adenocarcinoma

LUAD

cell proliferation

migration

invasion

apoptosis

Wnt/β-catenin pathway

therapeutic strategies