2023 World Conference on Lung Cancer (Posters)-EP02.03. Suppression of the Long Non-coding RNA LINC01279 Triggers Autophagy in Lung Cancer by Regulating SIN3A

EP02.03. Suppression of the Long Non-coding RNA LINC01279 Triggers Autophagy in Lung Cancer by Regulating SIN3A - PDF(Abstract)

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This study focused on the role of the long non-coding RNA LINC01279 in lung adenocarcinoma. The researchers found that LINC01279 is highly expressed in lung adenocarcinoma and may serve as a predictive factor for this type of cancer. By analyzing clinical samples, xenografts, and non-small-cell lung cancer cell lines, the study demonstrated that suppressing LINC01279 can inhibit tumor growth by activating autophagy and apoptosis. <br /><br />The researchers also investigated the molecular mechanisms underlying LINC01279 activity. They found that LINC01279 regulates the expression of focal adhesion kinase and extracellular-regulated kinase signaling. Additionally, it interacts with and stabilizes the transcriptional co-repressor SIN3A protein. Suppression of focal adhesion kinase and SIN3A also leads to apoptosis and inhibits tumor progression, suggesting that these proteins may mediate the oncogenic activity of LINC01279. <br /><br />These findings identify LINC01279 as a potential oncogene that plays a crucial role in the development of lung adenocarcinoma. They provide insights into the mechanisms through which LINC01279 promotes oncogenesis and suggest potential therapeutic targets for cancer diagnosis and prognosis. Overall, this study highlights the significance of long non-coding RNAs in lung cancer development and underscores the potential of LINC01279 as a therapeutic target.

Asset Subtitle

wenmei su

Meta Tag

Speaker wenmei su

Topic Tumor Biology: Preclinical Biology - Regulatory Mechanisms

Keywords

long non-coding RNA

LINC01279

lung adenocarcinoma

predictive factor

tumor growth

autophagy

apoptosis

molecular mechanisms

focal adhesion kinase