2023 World Conference on Lung Cancer (Posters)-EP02.04. PHLPP2 Enhances Anti-tumor Immunity by Promoting M1 Polarization of Macrophages via STAT3-related Pathway in NSCLC

EP02.04. PHLPP2 Enhances Anti-tumor Immunity by Promoting M1 Polarization of Macrophages via STAT3-related Pathway in NSCLC - PDF(Abstract)

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In this study presented at the WCLC 2023 conference, the researchers investigated the relationship between PHLPP2, an important tumor suppressor gene, and the immune response in lung cancer. The researchers analyzed data from the TCGA database and performed experiments using human lung adenocarcinoma cell lines to study the effects of PHLPP2 on immune cells. The results showed that PHLPP2 expression was associated with the tumor microenvironment, particularly macrophages in lung adenocarcinoma. Overexpression of PHLPP2 reduced the migration of macrophages, while knockdown of PHLPP2 had the opposite effect. In co-culture experiments, PHLPP2 expression increased the expression of anti-tumor M1 macrophages. Further investigation revealed a correlation between PHLPP2 and the JAK-STAT immune signaling pathway, specifically the key protein STAT3. Overexpression of PHLPP2 decreased STAT3 protein levels, whereas knockdown of PHLPP2 increased STAT3 expression. These findings suggest that PHLPP2 expression in lung adenocarcinoma cells promotes the polarization of anti-tumor M1 macrophages via the STAT3-related immune signaling pathway. This study contributes to a better understanding of the role of PHLPP2 in the tumor microenvironment and suggests its potential as a therapeutic target in lung cancer immunotherapy.

Asset Subtitle

Haihua Yang

Meta Tag

Speaker Haihua Yang

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

PHLPP2

tumor suppressor gene

immune response

lung cancer

macrophages

migration

M1 macrophages

JAK-STAT pathway

STAT3 protein

immunotherapy