2023 World Conference on Lung Cancer (Posters)-EP02.04. The Suppressed Peritumoral Immune Microenvironment Enhances the Progression of Primary Lung Cancer And Metastatic Liver Tumor

EP02.04. The Suppressed Peritumoral Immune Microenvironment Enhances the Progression of Primary Lung Cancer And Metastatic Liver Tumor - PDF(Abstract)

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This study focuses on the peritumoral microenvironment (pTME) of primary lung tumors and metastatic liver tumors in lung cancer patients. The pTME is known to support tumor growth, and understanding its role in liver metastasis is important for developing effective treatments. The researchers used a mouse model to mimic lung cancer with liver metastasis and analyzed the transcriptomic profile of the primary lung tumors, hepatic metastatic tumors, and their surrounding tissues using spatial next-generation sequencing.<br /><br />The results showed that the pTME of both the lung and liver tumors was over-expressed with specific genes, including Scd1 in the lung and Mt1/Mt2 in the liver. These genes were found to be involved in immune interactions that promoted tumor progression. In the lung, Scd1-expressing M2 macrophages were implicated, while in the liver, Mt1/Mt2 expressing hepatocytes and Bregs were involved.<br /><br />The study highlights the importance of the pTME in promoting cancer progression in both the lung and liver through immune interactions. These findings could have implications for diagnosing and predicting the prognosis of lung cancer with liver metastasis. They may also provide insights into potential biomarkers for targeted treatment strategies.<br /><br />In summary, this study sheds light on the molecular mechanisms of the peritumoral immune microenvironment in primary lung tumors and liver metastatic tumors. By understanding the interactions between immune cells and the tumor microenvironment, researchers hope to develop new diagnostic tools and effective treatment strategies for lung cancer patients with liver metastasis.

Asset Subtitle

KUAN-LI WU

Meta Tag

Speaker KUAN-LI WU

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

peritumoral microenvironment

primary lung tumors

metastatic liver tumors

lung cancer patients

tumor growth

liver metastasis

transcriptomic profile

immune interactions

tumor progression

targeted treatment strategies