2023 World Conference on Lung Cancer (Posters)-EP02.04. The Suppressed Peritumoral Immune Microenvironment Enhances the Progression of Primary Lung Cancer And Metastatic Liver Tumor

EP02.04. The Suppressed Peritumoral Immune Microenvironment Enhances the Progression of Primary Lung Cancer And Metastatic Liver Tumor - PDF(Slides)

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Researchers from Kaohsiung Medical University in Taiwan have conducted a study to explore the peritumoral immune microenvironment (pTME) of primary lung tumors and metastatic liver tumors in order to better understand tumor progression and identify potential treatment strategies. Lung cancer is the leading cause of cancer-related deaths worldwide, and liver metastases occur in 12% of lung cancer patients, leading to poorer outcomes.<br /><br />Using a mouse model injected with a Lewis lung carcinoma cell line, the researchers analyzed the transcriptomic profiles of the primary lung tumors, hepatic metastatic tumors, and their surrounding tissues using spatial next-generation sequencing. They found that the pTME in both the lung and liver were immuno-suppressive and promotive for tumor progression. In the lung, Scd1-expressing M2 macrophages were found to contribute to tumor growth, while in the liver, Mt1/Mt2 expressing hepatocytes and Bregs were identified as key players in promoting tumor progression.<br /><br />The study highlights the importance of the pTME in cancer progression and suggests that targeting the immune interactions in the microenvironment could be an effective treatment strategy for lung cancer with liver metastasis. Additionally, the findings could potentially be used as novel diagnostic and prognostic biomarkers for these types of cancer.<br /><br />Overall, this research provides valuable insights into the peritumoral immune microenvironment of primary lung tumors and metastatic liver tumors and has implications for the development of new treatment approaches in lung cancer with liver metastasis.

Asset Subtitle

KUAN-LI WU

Meta Tag

Speaker KUAN-LI WU

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

peritumoral immune microenvironment

lung tumors

liver tumors

tumor progression

treatment strategies

lung cancer

liver metastases

mouse model

transcriptomic profiles

spatial next-generation sequencing