2023 World Conference on Lung Cancer (Posters)-EP03.02. EGFR T790M Detection Differences by Original Mutation Types and Detection Samples

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This abstract is about a study conducted at the Shanghai Pulmonary Hospital, investigating the detection of the EGFR T790M mutation in non-small cell lung cancer (NSCLC) patients. The objective was to determine if the sample types and original EGFR mutations were associated with the incidence of the T790M mutation. The study included 893 NSCLC patients with treatment-resistance EGFR mutations, including 463 with 19del and 384 with L858R. There were also 39 patients with uncommon EGFR mutations and 7 patients with other mutations. The samples used for gene detection included plasma, cytological specimens, biopsy tissues, and pleural effusions.<br /><br />The results showed that the incidence of the T790M mutation was lower in plasma and tumor biopsy tissues compared to cytological samples and pleural effusions. Patients with uncommon EGFR mutations had a lower probability of developing the T790M mutation compared to those with 19del and L858R mutations. Among the patients with uncommon mutations, 2 were also found to have the L858R mutation. The incidence of the T790M mutation was lower in patients with the L858R mutation compared to those with the 19del mutation. Additionally, no mutation was detected in some samples.<br /><br />The study concluded that blood detection can be used as a supplementary method in re-detection after target therapy, but due to its high negative rate, it should not be solely relied upon. Advanced pleural effusions were suggested as an optional choice for sample collection. Patients with uncommon EGFR sensitive mutations showed a significantly lower incidence of the T790M mutation after EGFR-TKI treatment, suggesting that they may benefit from third-generation EGFR-TKIs.<br /><br />Overall, this study provides insights into the detection of the EGFR T790M mutation in NSCLC patients with different sample types and original EGFR mutations.

Asset Subtitle

Jian Ni

Meta Tag

Speaker Jian Ni

Topic Tumor Biology: Translational Biology - Drug Resistance

Keywords

EGFR T790M mutation

non-small cell lung cancer

NSCLC patients

sample types

original EGFR mutations

gene detection

plasma

cytological specimens

biopsy tissues

pleural effusions