2023 World Conference on Lung Cancer (Posters)-EP03.03. IS1160 Transposon Mycobacterium Tuberculosis Detection in Lung Cancer - A Preliminary Study

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Chronic inflammation and fibrosis have been associated with the development of lung cancer. Pulmonary tuberculosis (TB) is a chronic infection that can result in fibrosis and potentially contribute to lung cancer development. This study aimed to detect the DNA of Mycobacterium tuberculosis (M. Tb) in lung cancer patients.<br /><br />The researchers extracted DNA from histopathology specimens of non-small cell lung cancer (NSCLC) patients. They used the IS1160 Transposon Mycobacterium Tuberculosis and an end-point PCR method to detect the presence of M. Tb DNA. Clinical data was obtained from the medical records of the patients.<br /><br />The analysis included 10 different NSCLC patients, with various subtypes of lung cancer. Two patients had a previous history of pulmonary TB infection, while M. Tb was not detected in any patient at the time of diagnosis. Interestingly, IS1160 Transposon Mycobacterium Tuberculosis was detected in one patient who had adenocarcinoma and no history of TB infection.<br /><br />The study suggests that M. Tb DNA can be detected in lung cancer specimens, but further research is needed to understand its role in lung carcinogenesis. The findings contribute to the growing evidence linking pulmonary TB and lung cancer.<br /><br />References:<br />- Silva DR, Junior DFV, Müller AM, De Almeida CPB, Dalcin P de TR. Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence. J Bras Pneumol. 2013;39(4):484–9.<br />- Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P. Risk factors for lung cancer worldwide. Eur Respir J. 2016 Sep 1;48(3):889–902.<br />- Ho LJ, Yang HY, Chung CH, Chang WC, Yang S Sen, Sun CA, et al. Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study. PLoS One. 2021 May 1;16(5).<br />- Gunisha P, Madhavan HN, Jayanthi U, Therese KL. Polymerase chain reaction using IS6110 primer to detect Mycobacterium tuberculosis in clinical samples. Indian J Pathol Microbiol. 2001 Apr;44(2):97–102.<br />- Everatt R, Kuzmickiene I, Davidaviciene E, Cicenas S. Incidence of lung cancer among patients with tuberculosis: a nationwide cohort study in Lithuania. Int J Tuberc Lung Dis. 2016;20(6):757–63.<br />- Arrieta O, Molina-Romero C, Cornejo-Granados F, Marquina-Castillo B, Avilés-Salas A, López-Leal G, et al. Clinical and pathological characteristics associated with the presence of the IS6110 Mycobacterim tuberculosis transposon in neoplastic cells from non-small cell lung cancer patients. Sci Rep. 2022;12(1):1–11.<br />- Gonzalo-Asensio J, Pérez I, Aguiló N, Uranga S, Picó A, Lampreave C, et al. New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages. PLoS Genet. 2018;14(4):e1007282.

Asset Subtitle

Hana Faisal

Meta Tag

Speaker Hana Faisal

Topic Tumor Biology: Translational Biology - IO

Keywords

Chronic inflammation

fibrosis

lung cancer

pulmonary tuberculosis

Mycobacterium tuberculosis

DNA detection

non-small cell lung cancer

IS1160 Transposon Mycobacterium Tuberculosis

adenocarcinoma

lung carcinogenesis